ZK-261991 is an orally activeVEGFRtyrosine kinase inhibitor with anIC₅₀of 5 nM for VEGFR2.

ZK-261991 inhibits cellular receptor autophosphorylation in KDR-PAECs with an IC₅₀of 2 nM. ZK991 inhibits VEGFR-3 autophosphorylation concentration dependently with an IC₅₀of 20 nM^[1].

ZK991 results in a significantly reduced recruitment of CD11b⁺and LYVE-1⁺cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation^[1].

443.50

C₂₄H₂₅N₇O₂

886563-25-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.