您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Proxyphylline
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Proxyphylline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Proxyphylline图片
CAS NO:603-00-9
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 238.25
Formula C10H14N4O3
CAS No. 603-00-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO:>10 mM
Water:
Ethanol:
Solubility (In vivo)
Synonyms Monophylline, Spasmolysin
SMILES Code O=C(N1C)N(C)C2=C(N(CC(O)C)C=N2)C1=O
实验参考方法
In Vitro

In vitro activity: Proxyphylline has strong vasodilatory and cardiac stimulatory effects. It produces an increase in the coronary flow associated with a definite positive inotropic effect. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline.


Kinase Assay:


Cell Assay:

In VivoProxyphylline exhibits bronchodilatory effect in a double-blind cross-over study, it inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentration.
Animal model
Formulation & Dosage
References Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2.