VEGFR-2-IN-30

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VEGFR-2-IN-30

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

VEGFR-2-IN-30 是一种 VEGFR-2 抑制剂 (IC₅₀: 66 nM)。VEGFR-2-IN-30 还抑制 PDGFR、EGFR 和 FGFR1，IC₅₀s 分别为 180、98、82 nM。VEGFR-2-IN-30 将癌细胞阻滞在 S 期并诱导早期和晚期细胞凋亡 (apoptosis)。

生物活性

VEGFR-2-IN-30 is aVEGFR-2inhibitor (IC₅₀: 66 nM). VEGFR-2-IN-30 also inhibitsPDGFR,EGFRandFGFR1withIC₅₀s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrestscancercell at S-phase and induces early and lateapoptosis^[1].

IC₅₀& Target^[1]

VEGFR2

66 nM (IC₅₀)

体外研究
(In Vitro)

VEGFR-2-IN-30 (化合物 8f) (10 μM) 抑制 35% 的 UO-31 细胞生长^[1]。
VEGFR-2-IN-30 (10 μg/mL, 72 h) 抑制 HUVEC 细胞迁移^[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) 在阻滞 UO-31 细胞在S 期^[1]。
VEGFR-2-IN-30 (5.29 μM, 24 h) 诱导 UO-31 细胞凋亡^[1]。
VEGFR-2-IN-30 (5.29 μM, 24 h) 在 UO-31 细胞中增加 Bax 水平并下调 Bcl-2 水平^[1]。

Cell Migration Assay^[1]

Cell Line:	NHUVEC
Concentration:	10 μg/mL
Incubation Time:	72 h
Result:	Inhibited cell migration by 58.52%.

Apoptosis Analysis^[1]

Cell Line:	UO-31 cell
Concentration:	5.29 μM
Incubation Time:	24 h
Result:	Increased early apoptotic cells from 0.61% to 23.51% and late apoptotic cells from 0.13% to 9.28%. Increased the level of active caspase-3.

分子量

607.10

Formula

C₂₈H₂₃ClN₆O₄S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.