您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Anticancer agent 58
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Anticancer agent 58
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anticancer agent 58图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Anticancer agent 58 (compound 16) 对多种癌细胞具有抑制活性,特别是在 A549 和 T24 细胞中,IC50分别为 0.6 μM 和 0.7 μM。Anticancer agent 58 通过激活caspase 3/8/9活性诱导细胞凋亡 (apoptosis),也诱导 Ca2+ROS水平升高。Anticancer agent 58 在 T24 异种移植小鼠模型中能显著抑制肿瘤生长。
生物活性

Anticancer agent 58 (compound 16) has inhibitory activity against kinds ofcancercell lines, especially in A549 and T24 withIC50s of 0.6 μM and 0.7 μM, respectively. Anticancer agent 58 inducesapoptosisby activatingcaspase3/8/9activity, and induces an increase of Ca2+andROSincancercells. Anticancer agent 58 significantly decreases mitochondrial membrane potential. Anticancer agent 58 can suppress tumor growth in T24 mouse xenograft model[1].

IC50& Target

IC50: 0.6 μM in A549, 0.7 μM T24[1]

分子量

617.86

Formula

C39H55NO5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.