CAS NO: | 1639220-19-1 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Sigma-1 receptor antagonist 1 (compound 137) is a potent and selectivesigma-1 receptor (σ1R)antagonist, with a high binding affinity to σ1R receptor (Ki= 1.06 nM). Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain[1]. | ||||||||||||||||
IC50& Target | Ki: 1.06 nM (σ1R)[1] | ||||||||||||||||
体外研究 (In Vitro) | Sigma-1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (Ki= 1.06 nM) and good σ-1/2 selectivity (1344-fold)[1]. | ||||||||||||||||
体内研究 (In Vivo) | Sigma-1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain[1]. | ||||||||||||||||
分子量 | 380.31 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C19H23Cl2N3O | ||||||||||||||||
CAS 号 | 1639220-19-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 6.25 mg/mL(16.43 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |