Sigma-1 receptor antagonist 1 (compound 137) is a potent and selectivesigma-1 receptor (σ1R)antagonist, with a high binding affinity to σ1R receptor (K_i= 1.06 nM). Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain^[1].

Ki: 1.06 nM (σ1R)^[1]

Sigma-1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (K_i= 1.06 nM) and good σ-1/2 selectivity (1344-fold)^[1].

Sigma-1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain^[1].

380.31

Solid

C₁₉H₂₃Cl₂N₃O

1639220-19-1

Room temperature in continental US; may vary elsewhere.

DMSO : 6.25 mg/mL(16.43 mM;Need ultrasonic)

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