| CAS NO: | 135306-85-3 |
| 包装: | 1mg |
| 市场价: | 2436元 |
| Cas No. | 135306-85-3 |
| 别名 | Neurokinin-2 receptor antagonist |
| 化学名 | (3S,6S,9R,12R,15S,18S,21R)-9,15,18-tris((1H-indol-3-yl)methyl)-3,25-diamino-21-carbamoyl-6-(4-hydroxybenzyl)-12-isopropyl-4,7,10,13,16,19-hexaoxo-5,8,11,14,17,20-hexaazapentacosan-1-oic acid |
| Canonical SMILES | O=C([C@@H](C(C)C)NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](CC(C=C3)=CC=C3O)NC([C@H](CC(O)=O)N)=O)=O)=O)N[C@H](C(N[C@H](C(N[C@@H](C(N)=O)CCCCN)=O)CC4=CNC5=CC=CC=C45)=O)CC6=CNC7=CC=CC=C67 |
| 分子式 | C57H68N12O10 |
| 分子量 | 1081.24 |
| 溶解度 | Water : 1.43 mg/mL (1.20 mM) |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor. Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2]. Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2]. References: |
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