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N6-Cyclopentyladenosine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N6-Cyclopentyladenosine图片
CAS NO:41552-82-3
包装与价格：
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
N6-Cyclopentyladenosine (CPA) 是一种选择性腺苷 A1 受体激动剂，对人 A1、A2A 和 A3 受体的 Ki 值分别为 2.3 nM、790 nM 和 43 nM。
Cas No.41552-82-3
别名N6-环戊基TYLADENOSINE,CPA; UK-80882
化学名(2S,3R,4S,5R)-2-(6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Canonical SMILESO[C@H]1[C@@H](N2C3=NC=NC(NC4CCCC4)=C3N=C2)O[C@H](CO)[C@H]1O
分子式C15H21N5O4
分子量335.36
溶解度Up to 100nM in DMSO, UP to 25nM in ethonal, with warming
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N6-Cyclopentyladenosine is a selective agonist at adenosine 1 receptors (A1Rs) (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively, in transfected CHO cells).[1],[2] When microinjected into the rat brainstem, it increases blood pressure and heart rate.[3] It is effective for pain in normal and nerve-injured rats and shows anticonvulsant activity in a rat model of generalized seizures.[4],[5]

Reference:
[1]. Klotz, K.-N. Adenosine receptors and their ligands. Naunyn-Schmiedeberg's Arch. Pharmacol. 362(4), 382-391 (2000).
[2]. Klotz, K.-N., Hessling, J., Hegler, J., et al. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 357, 1-9 (1998).
[3]. Barraco, R.A., el-Ridi, M.R., Ergene, E., et al. Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns. Brain Res. Bull. 26(1), 59-84 (1991).
[4]. Gong, Q.-J., Li, Y.-Y., Xin, W.-J., et al. Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats. Brain Res. 1361, 23-30 (2010).
[5]. Jaishree, J., Kumaresan, S., Sudha, S., et al. Individual and combined effects of N6-cyclopentyladenosine, flunarizine and diazepam on aminophylline-induced recurrent generalized seizures in mice. Pol. J. Pharmacol. 55(4), 559-564 (2003).