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VU0357017 HCI
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VU0357017 HCI图片
CAS NO:1135242-13-5
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 369.89
Formula C18H28ClN3O3
CAS No. 1135242-13-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: ≥ 33 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILES O=C(N1CCC(NCCNC(C2=CC=CC=C2C)=O)CC1)OCC.[H]Cl
Synonyms CID 25010775, CID25010775, CID-25010775; VU0357017, VU-0357017, VU 0357017
实验参考方法
In Vitro

In vitro activity: VU0357017 is a M1-selective agonists that appear to activate M1 through actions at an allosteric site. Ki values of VU0357017 derived from competition binding experAiment is 9.91(rM1), 21.4 (rM2), 55.3 (rM3), 35 (rM4), and 50 (rM5), respectively.VU0357017 is a highly selective M1 agonist suggests that these compounds are unlikely to act at the highly conserved orthosteric site on M1 and are more likely to act as allosteric agonists.


Kinase Assay: VU0357017 is a M1-selective agonists that appear to activate M1 through actions at an allosteric site. Ki values of VU0357017 derived from competition binding experiment is 9.91(rM1), 21.4 (rM2), 55.3 (rM3), 35 (rM4), and 50 (rM5), respectively.


Cell Assay:

In VivoVU0357017 has robust efficacy in improving hippocampal-dependent learning in rats. VU0357017 enhances performance in Morris water maze and contextual fear conditioning in rats.
Animal model Rats
Formulation & Dosage
References ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.ACS Chem Neurosci. 2010;1(2):104-121.J Neurosci. 2012 Jun 20;32(25):8532-44. Bioorg Med Chem Lett. 2013 Jan 1;23(1):223-7.