| CAS NO: | 581-05-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 581-05-5 |
| 别名 | 美拉诺坦,α-Melanocyte-Stimulating Hormone |
| 化学名 | (4S,5Z,7S,8Z,10S,11Z,13S,14Z,16S,17Z,20Z,22S)-7-((1H-imidazol-5-yl)methyl)-16-((1H-indol-3-yl)methyl)-26-amino-10-benzyl-13-(3-guanidinopropyl)-5,8,11,14,17,20-hexahydroxy-22-((S)-2-((Z)-hydroxy(((S)-1-hydroxy-1-imino-3-methylbutan-2-yl)imino)methyl)pyrro |
| Canonical SMILES | CC([C@@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C)([H])CO)([H])CC2=CC=C(O)C=C2)([H])CO)([H])CCSC)([H])CCC(O)=O)([H])CC3=CN=CN3)([H |
| 分子式 | C77H109N21O19S |
| 分子量 | 1664.9 |
| 溶解度 | 25mg/ml in Water |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. α-Melanocyte-Stimulating Hormone (MSH), amide is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α–MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock[2]. α-Melanocyte-Stimulating Hormone (MSH), amide (α-MSH) has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases[2]. References: |
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