Escitalopram

立即咨询

Escitalopram

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

128196-01-0

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品名称

艾司西酞普兰
(S)-Citalopram
(S)-(+)-Citalopram

产品介绍

Escitalopram ((S)-Citalopram) 是外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂(SSRI)，K_i为 0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。Escitalopram 对多巴胺转运体 (DAT) 和去甲肾上腺素转运体 (NET) 均有选择性。Escitalopram 是研究抑郁症的抗抑郁药。

生物活性

Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selectiveserotonin reuptakeinhibitor (SSRI) with aK_iof 0.89 nM. Escitalopram has ~30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over bothdopamine transporter(DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression^[1]^[2].

IC₅₀& Target

Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)^[1]

体内研究
(In Vivo)

Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats^[3].
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively^[4].

Animal Model:	Male Sprague-Dawley rats^[3]
Dosage:	10 mg/kg
Administration:	I.p.; daily for 28 days
Result:	Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats.

Animal Model:	APP-PS1 hemizygous female mice (4 months of age)^[4]
Dosage:	2.5-5 mg/kg
Administration:	Daily; drinking water for a total of 4 months
Result:	At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.

Clinical Trial

分子量

324.39

Formula

C₂₀H₂₁FN₂O

CAS 号

128196-01-0

中文名称

艾司西酞普兰；依他普仑；右旋西酞普兰；依地普伦

结构分类

Others

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.