THIQ 是第一个选择性的黑皮质素 4 受体 (MC4R) 激动剂，对 hMC4R (IC50=1.2 nM, EC50=2.1 nM) 和 rMC4R (IC50=0.6 nM, EC50=2.9 nM) 具有高亲和力和效力。
| Cas No. | 312637-48-2 |
| 化学名 | (S)-N-((R)-1-(4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide |
| Canonical SMILES | ClC1=CC=C(C=C1)C[C@H](C(N2CCC(CC2)(CN3N=CN=C3)C4CCCCC4)=O)NC([C@H]5NCC6=CC=CC=C6C5)=O |
| 分子式 | C33H41ClN6O2 |
| 分子量 | 589.17 |
| 溶解度 | Soluble in Water |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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