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Sulprostone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sulprostone图片
CAS NO:60325-46-4
包装与价格：
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
Sulprostone (SHB 286) 是一种有效的选择性 EP3 受体激动剂。
Cas No.60325-46-4
别名硫前列酮; SHB 286; CP-34089; ZK-57671
化学名(Z)-7-((1R,2R,3R)-3-hydroxy-2-((R,E)-3-hydroxy-4-phenoxybut-1-en-1-yl)-5-oxocyclopentyl)-N-(methylsulfonyl)hept-5-enamide
Canonical SMILESO[C@H](C1)[C@H](/C=C/[C@H](COC2=CC=CC=C2)O)[C@@H](C/C=C\CCCC(NS(=O)(C)=O)=O)C1=O
分子式C23H31NO7S
分子量465.56
溶解度DMF: >10 mg/ml,DMSO: >14 mg/ml,Ethanol: >25 mg/ml,PBS pH 7.2: >4 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sulprostone is a metabolism resistant synthetic analog of PGE2.[1] It is a selective agonist for EP3 receptors with a Ki value of 0.35 nM at the human recombinant EP3-III receptor and an IC50 of 0.01 μM for the inhibition of PGE2 binding.[2],[3] Sulprostone is a potent stimulator of uterine smooth muscle contractions with high abortifacient activity.[4],[5]

Reference:
[1]. Schaaf, T.K., Bindra, J.S., Eggler, J.F., et al. N-(methanesulfonyl)-16-phenoxyprostaglandincarboxamides: Tissue-selective, uterine stimulants. Journal of Medicinal Chemistry 24, 1353-1359 (1981).
[2]. Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000).
[3]. Negishi, M., Harazono, A., Sugimoto, Y., et al. TEI-3356, a highly selective agonist for the prostaglandin EP3 receptor. Prostaglandins 48, 275-283 (1994).
[4]. Schillinger, E., Prior, G., Speckenbach, A., et al. Receptor binding in various tissues of PGE2, and sulprostone, a novel PGE2-derivative. Prostaglandins 18, 293-302 (1979).
[5]. Krishna, U., Gupta, A.N., Ma, H.K., et al. Randomized comparison of different prostaglandin analogues and laminaria tent for preoperative cervical dilation. Contraception 34, 237-251 (1986).