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M40
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
M40图片
CAS NO:143896-17-7
包装:1mg
市场价:1638元

产品介绍
M40 是一种有效的、非选择性的甘丙肽受体拮抗剂。
Cas No.143896-17-7
化学名(S,Z)-2-((Z)-((S)-2-((Z)-((2S,3R)-2-((Z)-((S)-2-((Z)-(2-amino-1-hydroxyethylidene)amino)-1-hydroxy-3-(1H-indol-3-yl)propylidene)amino)-1,3-dihydroxybutylidene)amino)-1-hydroxy-4-methylpentylidene)amino)-N'1-((3Z,5S,6Z,8S,9Z,11S,12Z,15Z,17S,18Z,20S)-1-((S)
Canonical SMILESCC(C[C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/CN)([H])CC1=CNC2=CC=CC=C12)([H])[C@@](O)([H])C)([H])CC(C)C)([H])CC(O)=N)([H])CO)([H])C)([H])CC3=CC=C(O)C=C3)([H])CC(C)C)([H]
分子式C94H145N23O24
分子量1981.33
溶解度Soluble to 1 mg/ml in sterile water
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

M40 is a potent, non-selective galanin receptor antagonist.

M40 (1 μM) displaces [mono[125IJodo-Tyr26]galanin from binding sites in the hippocampus, hypothalamus, and spinal cord. M40 has a lower affinity than galanin for all membranes. The IC50 values are 6 nM in the hippocampus, 15 nM in the hypothalamus, 12 nM in the spinal cord, and 3 nM in the insulinoma cells. M40 (1 μM) completely blocks 125I-labeled galanin-binding sites[1].

References:
[1]. Bartfai T, et al. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11287-91.