| CAS NO: | 723-46-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Cas No. | 723-46-6 |
| 别名 | 磺胺甲恶唑; Ro 4-2130 |
| 化学名 | 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide |
| Canonical SMILES | CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N |
| 分子式 | C10H11N3O3S |
| 分子量 | 253.28 |
| 溶解度 | ≥ 7.75mg/mL in DMSO |
| 储存条件 | Store at 2-8°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sulfamethoxazole (Ro 4-2130) is a sulfonamide bacteriostatic antibiotic. Sulfamethoxazole is being used for human and veterinary applications[1]. Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis. The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells. Bacterial resistance to sulfamethoxazole is caused by mutations in the enzymes involved in folic acid synthesis that prevent the drug from binding to it. References: |
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