H3R antagonist 2

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H3R antagonist 2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

H3R antagonist 2 (Compound 23) 是一种多靶点histamine H₃receptor (H₃R)拮抗剂，对 hH₃R 的K_i值为 170 nM。H3R antagonist 2 抑制乙酰胆碱酯酶 (acetylcholinesterase)、丁酰胆碱酯酶 (butyrylcholinesterase) 和人单胺氧化酶 B (human monoamine oxidase B (hMAO B))，IC₅₀值分别为180、880 和 775 nM。H3R antagonist 2 具有良好的抗神经性疼痛和记忆增强作用，能透过血脑屏障。

生物活性

H3R antagonist 2 (Compound 23) is a multitargethistamineH₃receptor(H₃R)antagonist with aK_iof 170 nM for hH₃R . H3R antagonist 2 shows inhibitory effects withIC₅₀values of 180, 880 and 775 nM foracetylcholinesterase,butyrylcholinesteraseandhumanmonoamine oxidaseB (hMAO B), respectively. H3R antagonist 2 shows favorable anti-neuropathic pain and memory-enhancing effects. H3R can across BBB^[1].

IC₅₀& Target

human H₃receptor

170 nM (Ki)

MAO-B

775 nM (IC₅₀)

Acetylcholinesterase

180 nM (IC₅₀)

Butyrylcholinesterase

880 nM (IC₅₀)

分子量

379.49

Formula

C₂₄H₂₉NO₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.