AChE/BChE-IN-6

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AChE/BChE-IN-6

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2416910-94-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

AChE/BChE-IN-6 (compound 22) 是一种有效的双重AChE/BChE抑制剂，对于 hBChE, hAChE 和 hMAO-B，其IC₅₀值分别为 0.809 μM、2.248 μM 和 >100 μM。AChE/BChE-IN-6 能够穿透血脑屏障 (BBB)。AChE/BChE-IN-6 可用于阿尔茨海默病 (AD) 的研究。

生物活性

AChE/BChE-IN-6 (compound 22) is a potent dualAChE/BChEinhibitor withIC₅₀values of 0.809 μM, 2.248 μM and >100 μM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB). AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research^[1].

IC₅₀& Target^[1]

hMAO-B

＞ 100 μM (IC₅₀)

hAChE

2.248 μM (IC₅₀)

hBCHE

0.809 μM (IC₅₀)

体外研究
(In Vitro)

AChE/BChE-IN-6 (compound 22) (1-100 μM; 48 hours) can cross the blood-brain barrier and has neuroprotective to human neuronal-like SH-SY5Y and liver HepG2 cells^[1].

Cell Viability Assay^[1]

Cell Line:	SH-SY5Y and HepG2 cells
Concentration:	1-100 μM
Incubation Time:	48 hours
Result:	Had non-cytotoxic at 20 μM on SH-SY5Y cells and at 50 μM on HepG2 cells.

分子量

366.50

Formula

C₂₃H₃₀N₂O₂

CAS 号

2416910-94-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.