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1-Methyl-2-undecyl-4(1H)-quinolone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1-Methyl-2-undecyl-4(1H)-quinolone图片
CAS NO:59443-02-6
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
1-Methyl-2-undecyl-4(1H)-quinolone 是一种有效的不可逆和选择性 B 型单胺氧化酶 (MAO-B) 抑制剂。1-Methyl-2-undecyl-4(1H)-quinolone 对 MAO-B 有选择性抑制作用，IC50和Ki值分别为 15.3 μM和 9.91 μM，但对 A 型 MAO (MAO-A) 活性没有抑制作用。1-Methyl-2-undecyl-4(1H)-quinolone 是一种喹诺酮类生物碱，从Evodia rutaecarpa HOOK. f. et THOMS 鲜叶和果实中分离得到。
生物活性

1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type Bmonoamine oxidase(MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition ofMAO-Bactivity with theIC50andKivalues of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as aquinolonealkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS[1][2].

IC50& Target[2]

MAO-B

15.3 μM (IC50)

MAO-B

9.91 μM (Ki)

体外研究
(In Vitro)

1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC50and Kivalues of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity[2].

分子量

313.48

Formula

C21H31NO

CAS 号

59443-02-6

结构分类
  • Alkaloids
  • Quinoline Alkaloids
来源
  • Plants
  • Rutaceae
  • Evodia rutaecarpa(Juss.) Benth.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.