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PAT-1251 Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PAT-1251 Hydrochloride图片
CAS NO:2098884-53-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PAT-1251 Hydrochloride 是一种口服有效的选择性赖氨酰氧化酶样蛋白 2 (LOXL2) 抑制剂,对 hLOXL2 和 hLOXL3 的IC50值分别为 0.71 和 1.17 μM,同时对小鼠、大鼠和狗 LOXL2 的抑制作用很强,IC50值分别为 0.10,0.12 和 0.16 μM。PAT-1251 Hydrochloride 可用于多种纤维性疾病的研究。
生物活性

PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, withIC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride is used in the research of fibrotic diseases.

IC50& Target

IC50: 0.10 μM (Mouse LOXL2), 0.12 μM (Rat LOXL2), 0.16 μM (Dog LOXL2), 0.71 μM (hLOXL2), 1.17 μM (hLOXL3)[1]

体外研究
(In Vitro)

PAT-1251 is a lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 shows highly selective for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO), in addition to the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with<10% inhibition at 10 μM[1].

Clinical Trial
分子量

435.80

Formula

C18H18ClF4N3O3

CAS 号

2098884-53-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.