您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Ladostigil
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Ladostigil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ladostigil图片
CAS NO:209394-27-4
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品名称
TV-3326
产品介绍
Ladostigil (TV-3326) 是一种口服有效的胆碱酯酶(cholinesterase)和脑选择性单胺氧化酶(MAO)的双重抑制剂,抑制MAO-BAChEIC50值分别为 37.1 和 31.8 μM。Ladostigil 具有神经保护,抗氧化和抗炎的作用,可用于抑郁症和阿尔茨海默症的研究。
生物活性

Ladostigil (TV-3326) is an orally active dual inhibitor ofcholinesteraseand brain-selectivemonoamine oxidase(MAO), withIC50s of 37.1 and 31.8 μM forMAO-BandAChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease[1][2].

IC50& Target[1]

MAO-B

37.1 μM (IC50)

AChE

31.8 μM (IC50)

体外研究
(In Vitro)

Ladostigil (1-10 μM) exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults[2].
Ladostigil (1-10 μM) has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells[2].

体内研究
(In Vivo)

Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats[4].
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats[3].

Animal Model:Pathogen-free (SPF) Sprague-Dawley rats[4]
Dosage:17 mg/kg
Administration:P.o. (added to the drinking water) daily for 6 weeks
Result:Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
Clinical Trial
分子量

272.34

Formula

C16H20N2O2

CAS 号

209394-27-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.