Dual AChE-MAO B-IN-3 (compound C10) is a potent dualAChE/MAO-Binhibitior, withIC₅₀values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site ofAChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research^[1].

Dual AChE-MAO B-IN-3 (compound C10) (0-100 μM, 24 h) exhibits low neurotoxicity, and (0-10 μM, 24 h) potently inhibits AChE enzymatic activity^[1].
Dual AChE-MAO B-IN-3 more effectively protects against mitochondrial dysfunction and oxidation thanDonepezil(HY-14566), strongly inhibits AChE-induced amyloid aggregation, and moderately reduces glutaraldehyde-induced phosphorylation of tau protein in SH-SY5Y cells^[1].

Dual AChE-MAO B-IN-3 (compound C10) (10 mg/kg, IP, once daily for 10 consecutive days) displays largely enhanced improvements in cognitive behaviors and spatial memory in a scopolamine-induced AD mice model with better efficacy thanDonepezil(HY-14566)^[1].

505.53

C₃₀H₂₆F₃NO₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.