Indatraline hydrochloride (Lu 19-005) is a non-selectivemonoamine transporterinhibitor that blocks the reuptake of neurotransmitters (dopamine,serotonin, andnorepinephrine) with efficacy similar to cocaine. Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride inducesautophagywhile simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis^[1].

monoamine transporter^[1]

Indatraline (0~5 μM; 24 hours; EGFP-LC3 stable cells) hydrochloride makes the concentration-dependent conversion of LC3^[1].
Indatraline (1~10 μM; 24 hours; HeLa cells) hydrochloride makes EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm^[1].
Indatraline (1~20 μM; smooth muscle cells) hydrochloride inhibits smooth muscle cells proliferation with an IC₅₀of 15 μM. Indatraline hydrochloride induces autophagy in cells. Indatraline hydrochloride affects AMPK/mTOR/S6K signaling axis^[1].

Indatraline (2 μM) hydrochloride inhibits neointimal accumulation of smooth muscle cells^[1].

328.66

C₁₆H₁₆Cl₃N

96850-13-4

茚达曲林盐酸盐

Room temperature in continental US; may vary elsewhere.

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