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Vimirogant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vimirogant图片
CAS NO:1802706-04-2
包装:1mg
市场价:7950元

产品名称
VTP-43742
产品介绍
Vimirogant (VTP-43742) 是一种选择性、具有口服活性的的RORγt抑制剂 (Ki=3.5 nM;IC50=17 nM)。Vimirogant 与 RORα 和 RORβ 比,高出 >1000 倍的选择性。Vimirogant 抑制小鼠脾细胞的 Th17 分化和 IL-17A 分泌 (IC50=57 nM),而不会影响 Th1,Th2 或 Treg 细胞的分化。Vimirogant 可用于研究自身免疫性疾病研究。
生物活性

Vimirogant (VTP-43742) is a potent, selective, and orally activeRORγtinhibitor (Ki=3.5 nM;IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus theRORαandRORβisotypes. Vimirogant inhibits Th17 differentiation andIL-17Asecretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research[1][2].

IC50& Target[1]

RORγt

3.5 nM (Ki)

RORγt

17 nM (IC50)

体外研究
(In Vitro)

Vimirogant inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM)[1].

体内研究
(In Vivo)

In the MOG35-55/CFA immunized mouse EAE model, Vimirogant (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord[1].

Clinical Trial
分子量

552.65

Formula

C27H35F3N4O3S

CAS 号

1802706-04-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.