CAS NO: | 1802706-04-2 |
包装: | 1mg |
市场价: | 7950元 |
生物活性 | Vimirogant (VTP-43742) is a potent, selective, and orally activeRORγtinhibitor (Ki=3.5 nM;IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus theRORαandRORβisotypes. Vimirogant inhibits Th17 differentiation andIL-17Asecretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research[1][2]. | ||
IC50& Target[1] |
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体外研究 (In Vitro) | Vimirogant inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM)[1]. | ||
体内研究 (In Vivo) | In the MOG35-55/CFA immunized mouse EAE model, Vimirogant (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord[1]. | ||
Clinical Trial | |||
分子量 | 552.65 | ||
Formula | C27H35F3N4O3S | ||
CAS 号 | 1802706-04-2 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |