CAS NO: | 911110-93-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potentRARagonist, withAC50s of 2.3 nM, 9.3 nM, and 22 nM forRARβ,RARγ,RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity ofGOT1in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity[1][2][3]. | ||||||||||||||||||||||||
IC50& Target | AC50: 2.3 nM (RARβ), 9.3 nM (RARγ), and 22 nM (RARα)[1] | ||||||||||||||||||||||||
体外研究 (In Vitro) | Adapalene sodium salt (1-200 μM; 24 h) inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC50s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively[2]. Cell Viability Assay[2]
Apoptosis Analysis[2]
Cell Cycle Analysis[3]
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体内研究 (In Vivo) | Adapalene sodium salt (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice[3].
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Clinical Trial | |||||||||||||||||||||||||
分子量 | 434.50 | ||||||||||||||||||||||||
Formula | C28H27NaO3 | ||||||||||||||||||||||||
CAS 号 | 911110-93-5 | ||||||||||||||||||||||||
中文名称 | 阿达帕林钠 | ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |