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sPLA2 inhibitor 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
sPLA2 inhibitor 1图片
CAS NO:393569-31-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
sPLA2 inhibitor 1 是一种 D-酪氨酸衍生物,是口服有效的分泌型磷脂酶 A2(sPLA2) 抑制剂,对人非胰腺分泌型 PLA2异构体 IIa (hnpsPLA2-IIa) 的IC50为 29 nM。sPLA2 inhibitor 1 具有抗炎活性。
生物活性

sPLA2 inhibitor 1, a D-tyrosine derivative, is an orally active, potentsecretoryphospholipase A2(sPLA2)inhibitor with anIC50of 29 nM for human nonpancreatic secretory PLA2isoform IIa (hnpsPLA2-IIa). sPLA2 inhibitor 1 has anti-inflammatory activity[1].

IC50& Target[1]

sPLA2

29 nM (IC50)

体内研究
(In Vivo)

sPLA2 inhibitor 1 (compound 2b; oral; 5 mg/kg/day; on Days 10-13 after inoculation with arthritogen) shows substantial inhibition of the oedema. Drug-treated rats shows mild capsular oedema and minimal infiltration of macrophages into the red pulp[1].

分子量

487.63

Formula

C31H37NO4

CAS 号

393569-31-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.