sPLA2 inhibitor 1, a D-tyrosine derivative, is an orally active, potentsecretoryphospholipase A₂(sPLA₂)inhibitor with anIC₅₀of 29 nM for human nonpancreatic secretory PLA₂isoform IIa (hnpsPLA₂-IIa). sPLA2 inhibitor 1 has anti-inflammatory activity^[1].

sPLA2 inhibitor 1 (compound 2b; oral; 5 mg/kg/day; on Days 10-13 after inoculation with arthritogen) shows substantial inhibition of the oedema. Drug-treated rats shows mild capsular oedema and minimal infiltration of macrophages into the red pulp^[1].

487.63

C₃₁H₃₇NO₄

393569-31-8

Room temperature in continental US; may vary elsewhere.

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