Lp-PLA2-IN-2

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Lp-PLA2-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2071636-15-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Lp-PLA2-IN-2 是一种有效的，选择性的脂蛋白相关的磷脂酶 A2(Lp-PLA2)抑制剂，抑制人重组 Lp-PLA2 的IC₅₀为 120 nM。

生物活性

Lp-PLA2-IN-2 is a potent and selectivelipoprotein-associatedphospholipaseA2 (Lp-PLA2)inhibitor, with anIC₅₀0f 120 nM for recombinant human Lp-PLA2^[1].

IC₅₀& Target

Lp-PLA2

120 nM (IC₅₀)

体外研究
(In Vitro)

Lp-PLA2-IN-2 inhibits Human Lp-PLA2 with anIC₅₀of 62 nM in PED6 assay^[1].

体内研究
(In Vivo)

Lp-PLA2-IN-2 (1 mg/kg; i.v.) treament in rats shows that the Cl, Vss and t_1/2values are 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively^[1].

Animal Model:	Male Han Wistar rats (250-300 g)^[1]
Dosage:	1 mg/kg
Administration:	i.v. (Pharmacokinetic Analysis)
Result:	The Cl, Vss and t_1/2values were 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively.

分子量

394.46

Formula

C₁₉H₂₃FN₂O₄S

CAS 号

2071636-15-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.