Azadirachtin B is an limonoid isolated from seed kernels ofAzadirachta indica. Azadirachtin B increasesalkaline phosphatase(ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against theEpstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties^[1][2][3].

Plutella xylostella^[1]
Alkaline phosphatase (ALP)^[2]
Epstein-Barr virus early antigen (EBV-EA)^[3]

Azadirachtin B (1 pM-100 μM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells^[1].
Azadirachtin B increases expression of RunX-2 ~2.5 fold at 10 nM concentration, ALP expression ~2.8 fold at 10 nM and 100 pM concentration and OCN expression ~2.5 folds at 10 nM as compared with control^[1].
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD₅₀of 4.85-1.06 μg/g body weight, in 92 h^[2].
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA)^[3].

On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity^[3].

662.68

Solid

C₃₃H₄₂O₁₄

106500-25-8

印楝素 B

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Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)