您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > CP-471474
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CP-471474
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CP-471474图片
CAS NO:210755-45-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CP-471474 是一个口服有效的、广泛的MMP抑制剂,IC50值分别为1170 nM (MMP-1)、0.7 nM (MMP-2)、16 nM (MMP-3)、13 nM (MMP-9) 和 0.9 nM (MMP-13)。
生物活性

CP-471474 is an orally active and panMMPinhibitor, withIC50values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively[1][2].

IC50& Target[1]

MMP-2

0.7 nM (IC50)

MMP-13

0.9 nM (IC50)

MMP-9

13 nM (IC50)

MMP-3

16 nM (IC50)

MMP-1

1170 nM (IC50)

体内研究
(In Vivo)

CP-471474 plasma levels following subcutaneous injection are 2,020 ng/mL (1 h postdose) to 160 ng/mL (6 h postdose)[2].
CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both[2].
CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months[2].

Animal Model:Guinea pigs weighing 400 to 450 g (COPD)[2].
Dosage:20 mg/kg (also supplemented daily by the diet (200 mg/200 g powdered chow)).
Administration:Subcutaneously (in 20% ethanol/80% polyethylene glycol), once a day during the entire course.
Result:Lungs derived from smoking animals treated with the compound demonstrated a statistically significant reduction in the destructive lesions.
Showed an increase of both pro–MMP-9 and its active form (lanes 5 to 8) as compared with control animals.
分子量

368.38

Formula

C16H17FN2O5S

CAS 号

210755-45-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.