Otaplimastat (SP-8203), amatrix metalloproteinase (MMP)inhibitor, blocksN-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in a competitive manner. Otaplimastat also exhibits anti-oxidant activity. Otaplimastat can be used for the research of brain ischemic injury^[1][2][3].

Otaplimastat (87.5-350 μM; 20 min) protects neuronal cells against NMDA-induced cell death in a competitive manner^[1].
Otaplimastat (350 μM) inhibits Ca²⁺influx following activation of NMDA receptors in primary cultured neuron^[1].
Otaplimastat (2-200 μM; pretreated for 4 h) significantly suppresses H₂O₂-induced cell death and reactive oxygen species production^[2].

Otaplimastat (10-20 mg/kg; i.p. 30 min before occlusion and 1 h after reperfusion) prevents ischemic neuronal death in the occlusion model of MCA^[1].
Otaplimastat (5-10 mg/kg; i.p. daily for 10 days) attenuates impairment of stroke-induced motor function^[2].

534.61

Solid

C₂₈H₃₄N₆O₅

1176758-04-5

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(187.05 mM;Need ultrasonic)

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