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ND-336
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ND-336图片
CAS NO:1807453-83-3
包装:5mg
市场价:7000元

产品介绍
ND-336 是基质金属蛋白酶(MMP)-2MMP-9MMP-14的选择性抑制剂,Ki分别为 85、150 和 120 nM。ND-336 通过降低炎症反应、促进创面血管生成和再上皮化,促进小鼠糖尿病创面愈合。
生物活性

ND-336 is a selective inhibitor ofmatrix metalloproteinase (MMP)-2,MMP-9, andMMP-14, withKis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2].

IC50& Target[1]

MMP-2

85 nM (Ki)

MMP-9

150 nM (Ki)

MMP-14

120 nM (Ki)

体内研究
(In Vivo)

ND-336 accelerates diabetic wound healing by decreasing inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thus reversing the pathological condition[1].
ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing[1].

Animal Model:Female diabetic db/db mice[1]
Dosage:0.05, 0.025, and 0.01 mg
Administration:Topical application; daily for 14 day
Result:Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle.
分子量

371.90

性状

Solid

Formula

C16H18ClNO3S2

CAS 号

1807453-83-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month