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BPHA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BPHA图片
CAS NO:193807-60-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
BPHA 是一种有效的具有口服活性的MMP-2MMP-9MMP-14抑制剂,IC50分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤作用。
生物活性

BPHA is a potent and orally activeMMP-2,MMP-9andMMP-14inhibitor withIC50s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibitMMP-1, -3, and -7 (the IC50s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects[1].

IC50& Target[1]

MMP-2

12 nM (IC50)

MMP-9

16 nM (IC50)

MMP-14

17 nM (IC50)

MMP-1

974 nM (IC50)

MMP-3

>1000 nM (IC50)

MMP-7

795 nM (IC50)

体外研究
(In Vitro)

BPHA does not inhibit typical serine proteinases (neutrophil elastase, plasmin, trypsin, and chymotrypsin), cysteine proteinases (cathepsins B and L), aspartic proteinase (HIV-1 protease), or metalloproteinase (aminopeptidase M)[1].

体内研究
(In Vivo)

Daily oral administration of 200 mg/kg BPHA in mice results in potent inhibition of tumor-induced angiogenesis, primary tumor growth, and liver metastasis. The growth inhibition activity of BPHA is 48% and 45% in a B16-BL6 melanoma and F2 hemangio-endothelioma model, respectively[1].

分子量

396.46

Formula

C21H20N2O4S

CAS 号

193807-60-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.