Ppc-1 是一种线粒体解偶联剂,可增加线粒体耗氧量,但不影响 ATP 的产生。Ppc-1 是一种细胞渗透性白介素 2 (IL-2) 抑制剂。Ppc-1 抑制革兰氏阴性牙周病原体Porphyromonas gingivalis的活性。Ppc-1 具有抗肥胖,抗菌和消炎的作用。
生物活性 | Ppc-1 is amitochondrialuncoupler. Ppc-1 enhancesmitochondrialoxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeateinterleukin-2 (IL-2)inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogenPorphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities[1][2][3][4]. |
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体外研究 (In Vitro) | Ppc-1 treatment (0-10 μM; 24 hours; Jurkat cells) significant inhibits IL-2 production in Jurkat cells with an IC50of 4 μM[2]. Ppc-1 (compound 6) has antiproliferative activities in K562 human leukemia, Hela cervical carcinoma, and 3T3-L1 mouse embryonic fibroblast cells. Ppc-1 shows about 50% inhibition at 15 μM in all cell lines. Ppc-1 inhibits the growth of K562 cells with an EC50of 13 μM[3].
Using the U937-3xκB-LUC human monocytic cell line, Ppc-1 dose-dependently inhibits the lipopolysaccharide-induced NF-κB activation[4].
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体内研究 (In Vivo) | Ppc-1 (0-10 mg /kg; Intraperitoneal injection; once a week; for 8 weeks; female ICR mice) treatment suppresses weight gain with no abnormal effects on liver or kidney tissues, and no evidence of tumor formation[1]. Serum fatty acid levels are significantly elevated in mice treated with Ppc-1, while body fat content remained low. After a single administration, Ppc-1 distributes into various tissues of individual animals at low levels. Ppc-1 stimulates adipocytes in culture to release fatty acids, which might explain the elevated serum fatty acids in Ppc-1-treated mice[1].
Animal Model: | Female ICR mice[1] | Dosage: | 0 mg /kg , 0.16 mg /kg, 0.8 mg /kg, 4 mg /kg, and 10 mg /kg | Administration: | Intraperitoneal injection; once a week; for 8 weeks | Result: | Suppresseed weight gain in animals. |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |