CAS NO: | 1874231-60-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally activeglutaminase1 (GLS1)inhibitor. Telaglenastat hydrochloride selectively inhibitsGLS1splice variantsKGA (kidney-type glutaminase)andGAC (glutaminase C)compared to GLS2. TheIC50s are 23 nM and 28 nM for endogenousglutaminasein mouse kidney and brain, respectively. Telaglenastat hydrochloride inudcesautophagyand has antitumor activity[1]. | ||||||||||||||||
体外研究 (In Vitro) | Telaglenastat (CB-839) (0.1-1000 nM; 72 hours) has antiproliferative activity in HCC1806 and MDA-MB-231 cells with IC50s of 49 nM and 26 nM, respectively[1]. Cell Proliferation Assay[1]
Apoptosis Analysis[1]
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体内研究 (In Vivo) | Telaglenastat (CB-839) (200 mg/kg; p.o.; twice daily for 28 days) has antitumor activity in xenograft models of TNBC[1].
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Clinical Trial | |||||||||||||||||
分子量 | 608.04 | ||||||||||||||||
Formula | C26H25ClF3N7O3S | ||||||||||||||||
CAS 号 | 1874231-60-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |