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NDB
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NDB图片
CAS NO:1660153-08-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
NDB 是一种选择性人FXRα (hFXRα)拮抗剂,可有效调节 FXRα 下游基因的转录。NDB可用于抗糖尿病研究。
生物活性

NDB is a selectivehuman FXRα (hFXRα)antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research[1].

IC50& Target

Human FXRα (hFXRα)[1]

体外研究
(In Vitro)

NDB induces rearrangements of helix 11 (H11) and helix 12 (H12, AF-2) by forming a homodimer of hFXRα-LBD, totally different from the active conformation in monomer state[1].
NDB (25 μM) effectively antagonizes the GW4064-stimulated FXR/RXR interaction and FXRα target gene expression in primary mouse hepatocytes, including the small heterodimer partner (SHP) and bile-salt export pump (BSEP)[1].

体内研究
(In Vivo)

NDB (24 mg/kg; intraperitoneal injection; once a day; for 4 weeks) efficiently decreases the gene expressions of phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6-pase), small heterodimer partner, and BSEP in db/db mice[1].

Animal Model:Male C57BL/6J db/db mice (8 weeks of age)[1]
Dosage:24 mg/kg
Administration:Intraperitoneal injection; once a day; for 4 weeks
Result:Decreased the gene expressions of PEPCK, G6-pase, small heterodimer partner, and BSEP.
分子量

471.42

Formula

C26H28Cl2N2O2

CAS 号

1660153-08-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.