Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor ofneutrophilelastase(NE)with apIC₅₀value of 7.9 nM, aK_ivalue of 9.4 nM and aK_dvalue of 9.5 nM^[1].

pIC: 7.9 nM; Ki: 9.4 nM; Kd: 9.5 nM (neutrophil elastas)^[1]

Alvelestat (20 μg/mL; 16 hours; HBE and A549 cells) treatment decreases cells death and decreases the levels of IL-1β, IL-6, and TNF-α in vitro^[2].

717.74

C₃₂H₃₀F₃N₅O₇S₂

1240425-05-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.