GYKI-47261 dihydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1217049-32-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

GYKI-47261 dihydrochloride 是一种竞争性、具有口服活性、选择性AMPA受体拮抗剂，IC₅₀为 2.5 μM，具有广谱抗惊厥和神经保护作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效诱导剂。

生物活性

GYKI-47261 dihydrochloride is a competitive, orally active, and selectiveAMPA receptorantagonist with anIC₅₀of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1^[1]^[2].

体内研究
(In Vivo)

GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice^[1].
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP^[1].

Animal Model:	Male C57 black mice, weighing 23-30 g^[1]
Dosage:	20 mg/kg
Administration:	I.p.
Result:	Reversed the MPTP-induced decrease in striatal concentrations.

分子量

395.71

Formula

C₁₈H₁₇Cl₃N₄

CAS 号

1217049-32-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.