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GYKI-47261 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GYKI-47261 dihydrochloride图片
CAS NO:1217049-32-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
GYKI-47261 dihydrochloride 是一种竞争性、具有口服活性、选择性AMPA受体拮抗剂,IC50为 2.5 μM,具有广谱抗惊厥和神经保护作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效诱导剂。
生物活性

GYKI-47261 dihydrochloride is a competitive, orally active, and selectiveAMPA receptorantagonist with anIC50of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1[1][2].

体内研究
(In Vivo)

GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice[1].
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP[1].

Animal Model:Male C57 black mice, weighing 23-30 g[1]
Dosage:20 mg/kg
Administration:I.p.
Result:Reversed the MPTP-induced decrease in striatal concentrations.
分子量

395.71

Formula

C18H17Cl3N4

CAS 号

1217049-32-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.