RO6889678

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RO6889678

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1578153-27-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

RO6889678 是一种高效的HBV衣壳结构抑制剂，具有复杂的吸收、分布、代谢和排泄 (ADME) 特征。RO6889678 是人肝细胞中 CYP3A4 和共调节蛋白的有效诱导剂。RO6889678 通过 CYP3A4 介导的氧化和 UDP-葡萄糖醛酸基转移酶 UGT1A3 和 UGT1A1 介导的直接葡萄糖醛酸化作用进行代谢。

生物活性

RO6889678 is a highly potentHBVcapsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation^[1].

IC₅₀& Target^[1]

CYP3A4

Clinical Trial

分子量

494.92

Formula

C₂₁H₂₀ClFN₄O₅S

CAS 号

1578153-27-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.