SAR7334 is a potent and specificTRPC6inhibitor, inhibiting TRPC6 currents withIC₅₀of 7.9 nM.

IC50: 7.9 nM (TRPC6 currents)^[3]

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca²⁺influx into cells with IC₅₀s of 9.5, 282 and 226 nM^[1][2][3], whereas TRPC4 and TRPC5-mediated Ca²⁺entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes^[1]. SAR7334 (1 μM) has negligible effect on SOCE^[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC₅₀of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents^[3].

SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)^[3].

367.87

Solid

C₂₁H₂₂ClN₃O

1333210-07-3

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 370 mg/mL(1005.79 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。