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TRPV3 antagonist 74a
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TRPV3 antagonist 74a图片
CAS NO:1432051-63-2
包装:5mg

产品介绍
TRPV3 antagonist 74a 是一种有效的选择性TRPV3拮抗剂。TRPV3 antagonist 74a 对其他离子通道面板显示无显著活性。TRPV3 antagonist 74a 可用于神经性疼痛的研究。
生物活性

TRPV3 antagonist 74a is a potent and selectiveTRPV3antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2].

IC50& Target[1][2]

TRPV3

 

体外研究
(In Vitro)

TRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca2+responses[2].

体内研究
(In Vivo)

TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly[2].
. TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold[1].

Animal Model:WT mice
Dosage:150 μg
Administration:Intradermal injection; 30 minutes
Result:The number of scratches decreased significantly.
分子量

338.32

Formula

C17H17F3N2O2

CAS 号

1432051-63-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.