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L-R4W2 TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-R4W2 TFA图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
L-R4W2 TFA 是一种有效的香草酸受体1 (VR1,TRPV1)的拮抗剂,IC50值为 0.1 μM。L-R4W2 TFA 可用于缓解疼痛的研究。
生物活性

L-R4W2 TFA is a potent antagonist ofvanilloid receptor 1 (VR1, TRPV1), with anIC50of 0.1 μM. L-R4W2 TFA may act as a potent analgesic[1][2].

IC50& Target[1]

TRPV1

0.1 μM (IC50)

分子量

1128.22

Formula

C48H72F3N21O8

Sequence

Arg-Arg-Arg-Arg-Trp-Trp-NH2

Sequence Shortening

RRRRWW-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.