L-R4W2 TFA

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L-R4W2 TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

产品介绍

L-R4W2 TFA 是一种有效的香草酸受体1 (VR1，TRPV1)的拮抗剂，IC₅₀值为 0.1 μM。L-R4W2 TFA 可用于缓解疼痛的研究。

生物活性

L-R4W2 TFA is a potent antagonist ofvanilloid receptor 1 (VR1, TRPV1), with anIC₅₀of 0.1 μM. L-R4W2 TFA may act as a potent analgesic^[1]^[2].

IC₅₀& Target^[1]

TRPV1

0.1 μM (IC₅₀)

分子量

1128.22

Formula

C₄₈H₇₂F₃N₂₁O₈

Sequence

Arg-Arg-Arg-Arg-Trp-Trp-NH2

Sequence Shortening

RRRRWW-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.