Remacemide hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

111686-79-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

盐酸瑞马酰胺
FPL 12924AA

产品介绍

Remacemide hydrochloride (FPL 12924AA) 是一种钠离子通道的中等强度抑制剂，是N-methyl-D-aspartate (NMDA) 受体的弱无竞争力拮抗剂，对于 MK-801 结合的 IC₅₀值为 68 μM，对于 NMDA 电流的 IC₅₀值为 76 μM。Remacemide hydrochloride 是一种抗惊厥剂。

生物活性

Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na⁺channel, is a weak uncompetitiveNMDA receptorantagonist with IC₅₀s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively^[1]. Remacemide hydrochloride is an anticonvulsant agent^[2].

IC₅₀& Target

IC50: 68-76 μM (NMDA receptor)^[1]
IC50:160.6 μM(sodium channel)^[2]

体外研究
(In Vitro)

Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na⁺channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC₅₀value of 160.6 μM^[2].

体内研究
(In Vivo)

Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats^[3].

Animal Model:	Female Sprague–Dawley rats ( 190-210 g )^[3]
Dosage:	100 mg/kg and 150 mg/kg
Administration:	Orogastric gavage; once a day; 7 days
Result:	Increased the number of sessions required to complete audio/visual discrimination (AVD) training.

分子量

304.81

Formula

C₁₇H₂₁ClN₂O

CAS 号

111686-79-4

中文名称

盐酸瑞马酰胺；盐酸瑞马西胺；盐酸立马醋胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.