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Esomeprazole magnesium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Esomeprazole magnesium salt图片
CAS NO:1198768-91-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(S)-Omeprazole magnesium salt
(-)-Omeprazole magnesium salt
产品介绍
Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) 是一种有效的具有口服活性质子泵抑制剂,可通过抑制胃壁细胞中的H+, K+-ATPase来降低酸分泌,并可用于胃食管反流疾病的研究。
生物活性

Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) is a potent and orally activeproton pump inhibitorand reduces acid secretion through inhibition of theH+, K+-ATPasein gastric parietal cells. Esomeprazole magnesium salt has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

IC50& Target

H+, K+-ATPase[1][2]

体外研究
(In Vitro)

Esomeprazole (25-100 μM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification[1].

Cell Viability Assay[1]

Cell Line:MDA-MB-468 cells
Concentration:25 μM, 50 μM, 75 μM, 100 μM
Incubation Time:20 hours
Result:Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.
体内研究
(In Vivo)

Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis[2].

Animal Model:C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury[2]
Dosage:30 mg/kg, 300 mg/kg
Administration:Oral gavage; daily; for 19 or 11 days
Result:Significantly inhibited the progression of fibrosis throughout the lungs of the animals.
Clinical Trial
分子量

369.72

Formula

C17H19MgN3O3S

CAS 号

1198768-91-0

中文名称

埃索美拉唑镁盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.