Omeprazole-13CD3 (H 16868-13CD3) is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), aproton pumpinhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition ofCYP2C19activity with aK_iof 2 to 6 μM^[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negativebacteria^[2].Omeprazole is a potent brain penetrantneutral sphingomyelinase (N-SMase)inhibitor (exosome inhibitor)^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

349.43

C₁₆¹³CH₁₆D₃N₃O₃S

1261395-28-1

奥美拉挫 13CD3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.