Amiodarone-d4 hydrochloride is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERGtails with anIC₅₀of ~45 nM^[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation viaERK1/2andp38 MAPKsignaling in fibroblasts^[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

685.80

Solid

C₂₅H₂₆D₄ClI₂NO₃

1216715-80-8

盐酸胺碘酮-d4

Room temperature in continental US; may vary elsewhere.