Rosuvastatin Sodium is a competitiveHMG-CoA reductase (HMGCR)inhibitor, with anIC₅₀of 11 nM. Rosuvastatin Sodium potently blockshERGcurrent with anIC₅₀of 195 nM^[2]. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction ofheat shock protein70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL)cholesterol, triglycerides, and C-reactive protein levels^[1][2][3].

IC50: 11 nM (HMG-CoA), 195 nM (hERG)^[1][2]

Rosuvastatin Sodium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms^[2].
Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Sodium (VLDL) in diabetes mellitus rats induced by Streptozocin^[4].

503.52

C₂₂H₂₇FN₃NaO₆S

147098-18-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.