NS309

立即咨询

NS309

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

18711-16-5

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

NS309 是一种有效、选择性的钙依赖性钾离子通道 SK/IK (Ca²⁺-activated SK/IK potassium channels) 的激活剂，但在 BK 通道上没有活性。

生物活性

NS309 is a potent and selective activator of theCa²⁺-activated SK/IK potassium channels, but displays no activity at BK channels^[1]^[2]^[3]^[4].

IC₅₀& Target

EC50: 0.62 μM (SK2)^[1], 0.3 μM (SK3)^[2], ~20 nM (K_Ca3.1/SK4)^[3], ~600 nM (K_Ca2/SK channels)^[3], 10 nM (hIK)^[4]

体外研究
(In Vitro)

NS309 (40 nM) activates both hSK3 and hIK channels, with the largest effect on hIK channels (8.5-fold increase in current compares to 1.9-fold increase in current for hSK3 channels)^[2].
NS309 (10 μM) significantly increases the whole cell SK currents and hyperpolarized detrusor smooth muscle (DSM) cells resting membrane potential^[5].
NS309 inhibits the spontaneous phasic contraction amplitude, force, frequency, duration and tone of isolated DSM strips in a concentration-dependent manner^[5].

体内研究
(In Vivo)

NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits^[6].

Animal Model:	Adult New Zealand white rabbits (2.5-3.0 kg)^[6]
Dosage:	2 mg/kg
Administration:	Intraperitoneal injection
Result:	Significantly improved neurological outcome of SCI/R challenged rabbits.

分子量

231.04

性状

Solid

Formula

C₈H₄Cl₂N₂O₂

CAS 号

18711-16-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(432.83 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.3283 mL	21.6413 mL	43.2826 mL
5 mM	0.8657 mL	4.3283 mL	8.6565 mL
10 mM	0.4328 mL	2.1641 mL	4.3283 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。