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Mitiglinide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mitiglinide图片
CAS NO:145375-43-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
KAD-1229 free acid anhydrous
S21403 free acid anhydrous
产品介绍
Mitiglinide (KAD-1229) 属于促胰岛素化合物,是一种 ATP 敏感的 K+通道 (KATPchannel) 拮抗剂。Mitiglinide 对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP通道) 具有高度特异性。Mitiglinide 可用于 2 型糖尿病的研究。
生物活性

Mitiglinide (KAD-1229), an insulinotropic agent, is anATP-sensitive K+(KATP) channelantagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATPchannel). Mitiglinide can be used for the research of type 2 diabetes[1][2].

IC50& Target

KATPchannel[1]

体外研究
(In Vitro)

Mitiglinide inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50of 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1].

体内研究
(In Vivo)

Mitiglinide (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].

Animal Model:Pregnant Wistar rats (12 weeks)[2]
Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:Oral administration
Result:Dose-dependently suppressed AUCglucoselevels.
Clinical Trial
分子量

315.41

Formula

C19H25NO3

CAS 号

145375-43-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.