E-4031 is a selectivehERGpotassium channelblocker for use in class III anti-arrhythmic studies^[1].

E-4031 (0.1-10 μM) significantly depolarises the maximum diastolic potential (MDP) and prolongs the action charge that depolarises MDP from -58.8+0.9 to -24.5±1.8 mV at 1 μM and from -58.2±2.1 to -19.6±1.8 mV at 10 μM in single SAN cells of New Zealand albinc rabbits^[2].
E-4031 (0.1-10 μM) can block part of the outward current during the depolarisation step as well as the tail current (I_TD) during subsequent repolarization in a dose-dependent manner, and depresses I_TDby 88 % at 10 μM in single SAN cells of New Zealand albinc rabbits^[2].

E-4031 (i.v., 50 μg/kg) reduces the net outward current of ventricular myocytes, prolongs the QT interval and activation-recovery interval (ARI) in all left ventricular (LV) layers, and increases transmural ARI dispersion in beagles^[1].

474.44

Solid

C₂₁H₂₉Cl₂N₃O₃S

113559-13-0

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : ≥ 50 mg/mL(105.39 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (210.77 mM); Clear solution; Need ultrasonic