Zolunicant

立即咨询

Zolunicant

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

188125-42-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

MM-110

产品介绍

Zolunicant (MM-110) 是一种有效的烟碱 α3β4 受体（nicotinic α3β4 receptors）的抑制剂，其IC₅₀为 0.90 μM。在大鼠模型中，Zolunicant 能降低吗啡、可卡因、甲基苯丙胺、尼古丁和乙醇等几种成瘾剂的自我给药能力。Zolunicant 可以被用于研究治疗多种形式的药物滥用。Zolunicant 对亚马逊利什曼原虫具有显著的杀利什曼原虫的作用。

生物活性

Zolunicant (MM-110) is a potent inhibitor againstnicotinic α3β4 receptorswith anIC₅₀of 0.90 μM to combat addiction. Zolunicant can decrease the self-administration of several addictive agents including morphine, cocaine, methamphetamine, nicotine, and ethanol in rat model. Zolunicant can be studied as a potential treatment for multiple forms of drug abuse^[1]. Zolunicant also reveals a potent leishmanicide effect againstLeishmaniaamazonensis^[2].

IC₅₀& Target

IC₅₀: 0.90 μM (nicotinic α3β4 receptor)^[1]

体外研究
(In Vitro)

Zolunicant (18-MC; 0.01-100 μM) shows an inhibitory activity against nicotinic α3β4 receptors with an IC₅₀of 0.90 μM^[1].
. Zolunicant (18-MCOR; 0-20 μg/ml; 24h) also shows antiamastigote activity against L. amazonensis-infected macrophage^[2].

Cell Viability Assay^[2]

Cell Line:	L. amazonensis-infected macrophage
Concentration:	0, 1, 10,15 and 20 μg/ml
Incubation Time:	24 h
Result:	Decreased the amastigote survival by 73, 84, and 92%, respectively in the treatment with 18-MCOR at 1, 10, or 20 μg/ml.

体内研究
(In Vivo)

Zolunicant (18-MC; Intravenous administration; 0-20 μg a day;14 days) decreases morphine self-administration by blocking α3β4 nicotinic receptors in the habenulo-interpeduncular pathway^[3].

Animal Model:	Naive female Long-Evans derived rats^[3]
Dosage:	0,10 and 20 μg
Administration:	Intravenous administration; once a day; 14 days
Result:	Infused into the medial habenula and interpeduncular nucleus decreased morphine self-administration (interpeduncular nucleus: F(5,29) = 6.89, P< 0.0001; medial habenula: F(4,28) = 3.07, P< 0.03).

分子量

368.47

Formula

C₂₂H₂₈N₂O₃

CAS 号

188125-42-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.