3M-011 is a potent dualtoll-like receptorTLR7/8agonist and a cytokine inducer. 3M-011 significantly inhibitsH3N2 influenza viralreplication in the nasal cavity. 3M-011 is also a potent adjuvant to radiotherapy that induces local and profound systemic immune responses during radiotherapy. 3M-011 strongly has antitumor action^[1][2][3].

3M-011 (0-100 μg/mL; 24 hours; B16-F10 melanoma cells) treatment can decrease B16-F10 melanoma cell counts^[1].
3M-011 potentiates natural killer (NK) cells cytotoxicity^[1].
The NF-κB reporter is stably integrated into HEK-293 cells that are subsequently transiently transfected with human or mouse TLR7 or TLR8. With all the TLRs tested, except mouse TLR8, stimulation with 3M-011 results in a dose-dependent induction of NF-κB-controlled luciferase activity. 3M-011 in humans activates both TLR7 and TLR8, whereas in mice, 3M011 activates only TLR7 and not TLR8^[1].

3M-011 (1 mg/kg; intravenous injection; every other day with six doses; female scid/NOD mice) treatment shows antitumor effects in scid/NOD mice bearing B16-F10 cells^[1].
Wild-type C57BL/6 mice are injected subcutaneously with different doses of 3M-011 (0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, or 10 mg/kg). 3M-011 induces a dose-dependent increase in serum concentrations of both TNF-α and IFN-α/β^[1].

391.49

C₁₈H₂₅N₅O₃S

642473-62-9

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