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TLR8 agonist 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TLR8 agonist 2图片
CAS NO:2412937-64-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
TLR8 agonist 2 是一种有效的选择性TLR8激动剂,对人 TLR8 的EC50为 3 nM。TLR8 agonist 2 对人 TLR7 的活性较低 (EC50为 33.33 μM)。
生物活性

TLR8 agonist2 is a potent and selectiveTLR8agonist with anEC50of 3 nM for humanTLR8.TLR8 agonist2 shows less active against humanTLR7(EC50of 33.33 μM)[1].

IC50& Target[1]

TLR8

3 nM (EC50)

TLR7

33.33 μM (EC50)

体外研究
(In Vitro)

TLR8 agonist 2 (Example 1) increases the levels of TNF-α, IL-12p40, IFN-γ, and IFN-α with EC50values 105 nM, 26 nM, 29 nM, and 2800 nM, respectively, in human peripheral blood mononuclear cells (hPBMC)[1].

体内研究
(In Vivo)

The pharmacokinetic related parameters of TLR8 agonist 2 (Example 1) in mice administered with the intravenous administration of 1 mg/kg and the oral administration of 5 mg/kg are detected. The T1/2of TLR8 agonist 2 are 0.25 h (1 mg/kg i.v.) and 0.5 h (5 mg/kg p.o.), the AUClastare 450 ng/mL*hr (i.v.) and 624 ng/mL*hr (p.o.). And for oral administration, the bioavailability (%F) is 27.7%[1]

分子量

326.40

Formula

C16H22N8

CAS 号

2412937-64-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.